Short Communication Inhibition of Dna Topoisomerase I and Ii, and Growth Inhibition of Mda-mb-231 Human Breast Cancer Cells by Bis-benzimidazole Derivatives with Alkylating Moiety
نویسندگان
چکیده
The purpose of the present study was to identify the cellular processes and targets affected by treatment with bis-benzimidazole derivatives with chloroalkyl and bromoalkyl moieties (1–4) in the estrogen receptor-negative MDA-MB-231 human breast cancer cells. Treatment of the cells revealed that these compounds inhibited DNA synthesis and irreversibly inhibited the proliferative activity of the cells. All drugs 1–4 inhibited relaxation of pBR 322 DNA induced by both topoisomerases, although topoisomerase I was 2to 9-fold more sensitive than topoisomerase II. This suggests that DNAbinding may be implicated in the cytotoxicity of bis-benzimidazole derivatives with alkylating moiety, possibly by inhibiting interactions between topoisomerases and their DNA targets.
منابع مشابه
Inhibition of DNA topoisomerase I and II, and growth inhibition of MDA-MB-231 human breast cancer cells by bis-benzimidazole derivatives with alkylating moiety.
The purpose of the present study was to identify the cellular processes and targets affected by treatment with bis-benzimidazole derivatives with chloroalkyl and bromoalkyl moieties (1-4) in the estrogen receptor-negative MDA-MB-231 human breast cancer cells. Treatment of the cells revealed that these compounds inhibited DNA synthesis and irreversibly inhibited the proliferative activity of the...
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